The Characterization of Instant Granule Melinjo Peel (Gnetum gnemon Linn.) as Alternative Treatment for Hyperuricemia
Downloads
Hyperuricemia is a non-communicable disease characterized by high levels of purine in the blood. One of the foods high in purine is melinjo chips. Instant granules from melinjo peel extract with a concentration of 450 mg have been proven to be effective as an anti-hyperuricemia treatment. To ensure the quality of the instant granule preparation, a quality evaluation was conducted to establish it as a new alternative in hyperuricemia therapy. The study aimed to assess the quality of the instant granule preparation of melinjo peel extract, including physical evaluation (particle size, loss on drying, and pH), characterization with Scanning Electron Microscope (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR), and specific microbial tests. The test results revealed that the particle size of the instant granules was classified as coarse particles, the Loss on Drying results showed 1.29% granule loss, and the pH evaluation indicated that the granules had a pH of 7.78. Based on the SEM characterization, the granules exhibited non-clumping and heterogeneous morphology. FTIR analysis showed the presence of quercetin in the instant granules of melinjo peel. Specific microbial testing indicated the absence of E. Coli in the preparation. Therefore, it is concluded that the instant granule preparation of melinjo peel has characteristics that make it suitable for development as an instant nutraceutical granule preparation for anti-hyperuricemia treatment.
Downloads
Rendra VD, Sakdiah, Zanaria TM. Hubungan konsumsi emping melinjo (Gnetum gnemon L) Aceh terhadap kadar asam urat pada mencit (Mus musculus L). Jurnal Kedokteran Syiah Kuala. 2023 Mar;23(1):24–8. Doi: 10.24815/jks.v23i1.28008
Dehlin M, Jacobsson L, Roddy E. Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Vol. 16, Nature Reviews Rheumatology. Nature Research; 2020. p. 380–90. Doi: https://doi.org/10.1038/s41584-020-0441-1
Santoso BN, Suwangto EG, Iryaningrum MR. The Association Between Knowledge About Gout Arthritis with NSAID and Allopurinol Consumption in Rumah Susun Penjaringan. Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer). 2021 Apr 13;4(1):18. Doi:https://doi.org/10.22146/rpcpe.58359
Wijayanti L, Wahyudi A, Septianingrum Y. The Correlation Between Lifestyle and Increased Uric Acid Levels In The Elderly. Nurse and Holistic Care. 2021 Sep 8;1(2):48–55. Doi:https://doi.org/10.33086/nhc.v1i2.2212
Sari M, Rahmawati SI, Izzati FN, Bustanussalam, Putra MY. Antioxidant Activity of Ethanolic Extract of Peel and Seed Melinjo (Gnetum gnemon) Based on Color Variations. In: Proceedings of the 1st International Conference for Health Research–BRIN (ICHR 2022). Dordrecht: Atlantis Press International BV; 2023. p. 255–65. Doi: 10.2991/978-94-6463-112-8_25
Hasby Puarada S, Nadia R, Gurning S, Harahap WU. Pemanfaatan Limbah Kulit Buah Melinjo (Gnetum gnemon L) Menjadi Produk Olahan Keripik Kulit Buah Melinjo. Jurnal Pengabdian kepada Masyarakat. 2020 Dec 1;11(4):567–72. Doi:https://doi.org/10.26877/e-dimas.v11i4.6464
Hasan AEZ, Husnawati, Puspita CA, Setiyono A. Efektivitas Ekstrak Kulit Melinjo (Gnetum gnemon) sebagai Penurun Kadar Asam Urat pada Tikus Putih (Rattus norvegicus) Hiperurisemia. Current Biochemistry. 2020 Jan 6;7(1):21–8. Doi: https://doi.org/10.29244/cb.7.1.3
Angel V, Parhusip AJN. Karakterisasi Ekstrak Kulit Melinjo (Gnetum gnemon L.) Merah Sebagai Komponen Antibakteri. FaST - Jurnal Sains dan Teknologi (Journal of Science and Technology). 2024 May 31;8(1):59. Doi: http://dx.doi.org/10.19166/jstfast.v8i1.7598
Sari NK, Soemardji AA, Fidrianny I. Kajian Pengaruh Ekstrak Daun dan Kulit Buah Melinjo pada Tikus Jantan Hiperurisemia Biji Melinjo (Gnetum Gnemon L.). Journal of Medicine and Health. 2019;2(4):956–64. Doi: https://doi.org/10.28932/jmh.v2i4.1840
Sari DP, Fahriati AR, Maelaningsih FS. Formulation of Instant Granules from Ethanolic Extract of Melinjo Peel (Gnetum gnemon L) Extract as Anti-Hyperuricemia. Jurnal Kefarmasian Indonesia. 2023 Aug 31;13(2):140–9. Doi:https://doi.org/10.22435/jki.v13i2.6290
Julianti TB, Mentari IA, Wikantyasning ER, Azzahra S, Hairunisa I. Formulasi dan Uji Antioksidan Formula Granul Effervescent Ekstrak Kulit Buah Pulasan (Nephelium mutabile Blume). Jurnal Pharmascience. 2022 Oct 1;9(2):285–99. Doi: http://dx.doi.org/10.20527/jps.v9i2.13717
Kalalo T, Yamlean PVY, Citraningtyas G. Pengaruh Penggunaan Pati Kulit Nanas (Ananas comosus (L.) Merr.) sebagai Bahan Pengikat pada Granul CTM. PHARMACON. 2019 Feb 28;8(1):203. Doi: https://doi.org/10.35799/pha.8.2019.29255
Putriana NA, Mardawati E, Wardhana YW, Afifah N, Wulandari A, Wira DW, et al. Formulation and Evaluation of instant granules from Ketapang Badak fruit (Ficus lyrata Warb) using wet granulation method as an antioxidant supplement. Indonesian Journal of Pharmaceutics. 2022 Jan 28;3(3):116. Doi:https://doi.org/10.24198/idjp.v3i3.37062
Mentor S, Cummings F, Fisher D. Preparation of biological monolayers for producing high-resolution scanning electron micrographs. PLoS One. 2022 Jul 8;17(7):e0266943. Doi: https://doi.org/10.1371/journal.pone.0266943
Nurfitriyana, Fithri NA, Yanuarti R. Analisis Interaksi Kimia Fourier Transform Infrared (FTIR) Tablet Gastrorentif Ekstrak Daun Petai (Parkia speciosa Hassk) dengan Polimer HPMC-K4M dan Kitosan. 2022 Aug;03(02):27–33. Doi: https://doi.org/10.62702/ion.v3i2.69
Damayanti T, Purwantisari S. Deteksi Escherichia coli Dalam Sampel Obat Tradisional Jenis Jamu Bubuk di Balai Besar Pengawasan Obat dan Makanan (BBPOM) Semarang. Jurnal Akademika Biologi. 2020 Jul;9(2):15–9. Retrieved from: https://ejournal3.undip.ac.id/index.php/biologi/article/view/29308.
Imtihani HN, Alfreeda S, Arif JRA. Pengaruh Variasi Disintegran Avicel PH-102 dan Primogel terhadap Karakteristik Co-Processed Excipient. Jurnal Ilmiah Medicamento. 2023 Mar 30;9(1):9–15. Doi: https://doi.org/10.36733/medicamento.v9i1.4635
Pramesti N, Novidahlia N, Siti Nurlaela R, Pangan JT, Fakultas G, Pangan I, et al. Penggunaan Ekstrak dan Perisa Jahe terhadap Potensi Kegumpalan pada Serbuk Pemanis Intensitas Tinggi. 2024;3(4). Doi: https://doi.org/10.30997/karimahtauhid.v3i4.13015
Fatmawati A, Elvana, Elvana A. Optimasi Formula pada Granul Paracetamol dengan Variasi Komposisi Bahan Pengisi Laktosa dan Avicel PH 101 Serta Evaluasi Parameter Kadar Lembab Moisture Content dan Loss on Drying. Indonesian Pharmacy and Natural Medicine Journal. 2020;4(1):25–32. Doi: http://dx.doi.org/10.21927/inpharnmed.v4i1.1806
Utami SM, Ismaya NA, Ratnaningtyas TO, Yunarto N. Formulasi Sediaan Minuman Serbuk Fungsional Kombinasi Biji Jagung (Zea mays L. ) dan Madu. Jurnal Kefarmasian Indonesia. 2022 Aug 26;109–17. Doi: https://doi.org/10.22435/jki.v0i0.5536
Pratama R, Roni A, Fajarwati K. Uji Sifat Fisik Granul Instan Ekstrak Pegagan (Centella asiatica) Menggunakan Metode Fluid Bed Dryer. Journal of Pharmacopolium. 2022 Dec;5(3):299–304. Doi: https://doi.org/10.36465/jop.v5i3.1062
Solikhati A, Rahmawati RP, Kurnia SD. Analisis Mutu Fisik Granul Ekstrak Kulit Manggis dengan Metode Granulasi Basah. Indonesia Jurnal Farmasi. 2022;7(1):1–9. Doi:https://doi.org/10.26751/ijf.v7i1.1421
Parhi B, Bharatiya D, Swain SK. Application of quercetin flavonoid based hybrid nanocomposites: A review. Saudi Pharmaceutical Journal. 2020 Dec 1;28(12):1719–32. Doi:https://doi.org/10.1016/j.jsps.2020.10.017
Arifin KZ, Sulistyani N. Uji Kandungan Bakteri Escherichia coli Dalam Produk Obat Tradisional yang Dijual di Pasar Beringharjo. Jurnal Fitofarmaka Indonesia. 2023;10(1):11–6.Doi:https://doi.org/10.33096/jffi.v10i1.883
Copyright (c) 2025 Jurnal Kefarmasian Indonesia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
