Odds Ratio of Increase in Hemoglobin Level Associated with Consumption of Songgak Coffee in Patients with Pulmonary TB

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Pulmonary TB cases in Indonesia are the second highest in the world. The incidence of Anemia in pulmonary TB patients can be as high as 90%. Anemia can lead to poor outcomes in the recovery of pulmonary TB. Songgak coffee is a coffee with a mixture of spices that is commonly consumed by the people of Central Lombok to make the body healthy and increase vitality, including pulmonary TB patients. Songgak coffee is made from 7 types of spices mixed with coffee. The results of previous research show that Songgak coffee has quite good antioxidant content and is an immunostimulant. Antioxidants may increase Hemoglobin levels. This was a case-control study. A total of 26 new pulmonary TB patients were divided into 2 groups. Group A received songgak coffee as an additional anti-TB drug, while group B received anti-TB drug therapy alone. Hemoglobin levels in groups A and B were measured before drug administration and 14 days after treatment. The data collected were nominal data, reported as increasing and non-increasing. A total of 12 out of 13 patients in group A had an increase in Hemoglobin, while only 1 person in group B had an increase in Hemoglobin. The odds ratio value for increasing Hemoglobin levels in pulmonary TB patients who consume songgak is 12. The odds ratio value for increasing Hemoglobin in pulmonary TB patients taking songgak is 12. The odds ratio value for increasing Hemoglobin levels in pulmonary TB patients who take Songgak is 12 times higher than in pulmonary TB patients who do not take Songgak.
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World Health Organization (WHO). Global Tuberculosis Report. Geneva: WHO; 2022.
Kementerian Kesehatan RI. Kasus TBC Tinggi Karena Perbaikan Sistem Deteksi dan Pelaporan. 29 Januari 2024. 2024 [cited 2024 Jul 12]. Available from: https://sehatnegeriku.kemkes.go.id/baca/rilis-media/20240129/2644877/kasus-tbc-tinggi-karena-perbaikan-sistem-deteksi-dan-pelaporan/
Provinsi NTB. Jumlah Penderita Tuberculosis Provinsi NTB-SMT I 2023. Mataram; 2023. Available from: https://data.ntbprov.go.id/dataset/jumlah-penderita-tuberculosis
Brittenham GM, Moir-meyer G, Abuga KM, Datta-mitra A, Cerami C, Green R, et al. Biology of Anemia : A Public Health Perspective. The Journal of Nutrition. 2023;153(May):S7–28. Available from: https://doi.org/10.1016/j.tjnut.2023.07.018
Araújo-pereira M, Krishnan S, Salgame P, Manabe YC, Hosseinipour MC, Bisson G, et al. Effect of the relationship between Anemia and systemic in fl ammation on the risk of incident tuberculosis and death in people with advanced HIV : a sub-analysis of the REMEMBER trial. aClinicalMedicine. 2023;60(June):1–12.
Kristiana L, Paramita A, Maryani H, Andarwati P. Eksplorasi Tumbuhan Obat Indonesia untuk Kebugaran : Analisis Data Riset Tumbuhan Obat dan Jamu Tahun 2012, 2015 dan 2017. Jurnal Kefarmasian Indonesia. 2022;12(1):79–89.
Foss K, Przybyłowicz KE, Sawicki T. Antioxidant Activity and Profile of Phenolic Compounds in Selected Herbal Plants. Plant Foods Human Nutrition. 2022;77:383–9. Available from: https://doi.org/10.1007/s11130-022-00989-w
Yunarto N, Mawadatun U, Reswandaru UN, Sopian A, Isnawati A, Alegantina S. Antioxidant and Inhibition Lipase Enzyme Activity of Centella asiatica Leaf Extract. Jurnal Kefarmasian Indonesia. 2023;13(2):167–74.
Wulandari L, Nugraha AS, Himmah UA. Penentuan Aktivitas Antioksidan dan Antidiabetes Ekstrak Daun Matoa (Pometia pinnata J.R. Forst. & G. Forst.) secara In Vitro. Jurnal Kefarmasian Indonesia. 2021;11(2):132–41.
Widodo H, Sismindari S, Asmara W, Rohman A. Antioxidant activity, total phenolic and flavonoid contents of selected medicinal plants used for liver diseases and its classification with chemometrics. Journal of Applied Pharmaceutical Science. 2019;9(6):99–105.
Dewi L, Khusuma A, Muliasari H, Permatasari L, Widodo H. The principal component analysis of antioxidant activities of Songgak , a traditional herbal drink in West Nusa Tenggara, Indonesia. Food Research. 2024;8(October):245–52.
Cotoraci C, Ciceu A, Sasu A, Hermenean A. Natural Antioxidants in Anemia Treatment. International Journal of Molecular Sciences. 2021;22:1883.
Harun H, Daud A, Hadju V, Pratama C, Arief P, Talebe T, et al. Antioxidant effect of Moringa oleifera leaves in hemoglobin oxidation compare with vitamin C. Enfermería Clínica. 2020;30(S4):18–21. Available from: https://doi.org/10.1016/j.enfcli.2019.10.033
Cotoraci C, Ciceu A, Sasu A, Hermenean A. Natural Antioxidants in Anemia Treatment. International Journal of Molecular Science. 2021;22:1–35.
Gelaw Y, Getaneh Z, Melku M. Anemia as a risk factor for tuberculosis : a systematic review and meta-analysis. Environmental Health and Preventive Medicine. 2021;26(13):1–15.
Balushi H Al, Hannemann A, Rees D, Brewin J, Gibson JS. The Effect of Antioxidants on the Properties of Red Blood Cells From Patients With Sickle Cell Anemia. Frontiers in Physiology. 2019;10(August).
Szumilas M. Explaining Odds Ratios. Journal of the Canadian Academy of Child and Adolescent Psychiatry. 2010;19(August):227–9.
Jenkins DG, Quintana-ascencio PF. A solution to minimum sample size for regressions. PLoS One. 2020;15(2):1–15.
Kerr S, Jeffrey K, Millington T, Bedston S, Ritchie SL, Simpson CR, et al. Understanding and reporting odds ratios as rate-ratio estimates in case-control studies. Journal of Global Health. 2023;13(04101).
George A, Stead TS, Ganti L. What ’s the Risk : Differentiating Risk Ratios, Odds Ratios, and Hazard Ratios? Cureus. 2020;12(8):6–13.
World Health Organization (WHO). Guideline on haemaglobin cutoffs to define Anemia in individuals and populations. Geneva; 2024.
Gil-santana L, Cruz LAB, Arriaga MB, Mirand PFC, Fukutani KF, Silve PS, et al. Tuberculosis-associated anemia is linked to a distinct inflammatory profile that persists after initiation of antitubercular therapy. Scientific Reports. 2019;9(December 2018):1–8.
Mukherjee A, Kaeley N, Dhar M, Kumar S, Bhushan B. Prevalence , characteristics , and predictors of tuberculosis associated anemia. Journal of Family Medicine and Primary Care. 2019;8(7):2445–9.
Minardi ML, Fato I, Gennaro F Di, Mosti S, Mastrobattista A, Cerva C, et al. Common and Rare Hematological Manifestations and Adverse Drug Events during Treatment of Active TB : A State of Art. microorganisms. 2021;1447(9):1–15.
Manchanda N. 16 - Anemias: Red blood cell morphology and approach to diagnosis. In: Rodak’s Hematology Clinical Principles and Applications . Sixth Edit. Elsevier Inc.; 2019. p. 251–63. Available from: https://doi.org/10.1016/B978-0-323-53045-3.00025-8
Cercamondi CI, Stoffel NU, Moretti D, Zoller T, Swinkels DW, Zeder C, et al. Iron homeostasis during anemia of inflammation : a prospective study of patients with tuberculosis. Blood . 2021;138(15):1293–303. Available from: http://dx.doi.org/10.1182/blood.2020010562
Banerjee S, Katiyar P, Kumar L, Kumar V, Sagar S, Krishnan V, et al. Free Radical Biology and Medicine Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1 / IL6-STAT3 signaling pathway. Free Radic Biol Med . 2021;168(March):189–202. Available from: https://doi.org/10.1016/j.freeradbiomed.2021.03.019
Sagar P, Angmo S, Sandhir R, Rishi V, Yadav H, Kumar N. Pharmacology & Therapeutics Effect of hepcidin antagonists on anemia during in fl ammatory disorders. Pharmacology & Therapeutics. 2021;226(107877):1–14. Available from: https://doi.org/10.1016/j.pharmthera.2021.107877
Kementerian Kesehatan Republik Indonesia. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis. Jakarta; 2020.
Kashyap A, Bhagat M, Mahajan R. Anemia and Nutritional Status in Tuberculosis Patients. Int J Appl Basic Med Res. 2021;11(4):226–30.
Dewi LBK, Khusuma A, Sundayani L, Muliasari H. Immunomodulatory Effect of Songgak : In-vivo Experiment. International Journal of Applied and Basic Medical Research. 2023;24(5):411–5.
Mehram EB, Ahmed SAS, Yousif A. Role of Oxidant/Antioxidant Status in the Pathogenesis of Iron-Deficiency Anemia: Case Study on Children of Qalyubiyya and Minoufiya Governorates, Egypt. Bulletin of National Nutrition Institute of the Arab Republic of Egypt. 2020;55:39–72.
Yadav K, Mishra OP, Khandhadiya K, Mishra SP, Mishra A, Singh A, et al. Markers of oxidative stress in children with iron de fi ciency anemia. Pediatric Hematology Oncology Journal. 2024;9(1):9–14. Available from: https://doi.org/10.1016/j.phoj.2023.12.009
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