Evaluation of the Use of Antibiotics in the COVID-19 Ward at A North Jakarta Hospital

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The misuse of antibiotics can lead to antibiotic drug resistance, which can increase morbidity and mortality. In order to stop the emergence of antibiotic drug resistance, the WHO recommends routinely assessing the usage of antibiotics. When the COVID-19 epidemic broke out, antibiotic consumption significantly increased compared to the prior year. The panic buying phenomenon also appeared during the COVID-19 pandemic. As a result of this circumstance, medications like antibiotics become rare. The abuse of antibiotics during the COVID-19 pandemic may have contributed to the spread of antibiotic resistance more frequently. This study was conducted to evaluate and describe the use of antibiotic drugs in COVID-19 ward patients at a North Jakarta regional hospital for the period April 2020 – April 2021. This study was an observational study design. The Gyssens method and the Anatomical Therapeutic Chemical/Defined Daily Doses (ATC/DDD) methodology, respectively, evaluate the effectiveness of antibiotic use on a quantitative and qualitative level. There were 24 different types of antibiotics used, and 161 respondents all met the criterion for inclusion. The most widely used antibiotic was azithromycin, with a DDD/100 patient days value of 25.15. According to Gyssen’s evaluation, 92.6% of antibiotic usage was rational and 7.4% was irrational.
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Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia nomor 8 tahun 2015 tentang program pengendalian resistensi antimikroba di rumah sakit. Kementerian Kesehatan Republik Indonesia, 8 Indonesia: www.peraturan.go.id; 2015.
May L, Klein EY, Rothman RE, Laxminarayan R. Trends in antibiotic resistance in coagulase-negative Staphylococci in the United States, 1999 to 2012. Antimicrobial Agents Chemotherapy. 2014 Mar;58(3):1404–09. doi: 10.1128/AAC.01908-13
Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia tentang Pedoman Umum Penggunaan Antibiotika Nomor 2406/MENKES/PER/XII/2011. Indonesia; 2011.
Parathon H, Kuntaman K, Widiastoety TH, Muliawan BT, Karuniawati A, Qibtiyah M, et al. Progress towards antimicrobial resistance containment and control in Indonesia. BMJ. 2017 Sep 5;358:j3808. doi: 10.1136/bmj.j3808.
Abelenda-Alonso G, Padullés A, Rombauts A, Gudiol C, Pujol M, Alvarez-Pouso C, et al. Antibiotic prescription during the COVID-19 pandemic: A biphasic pattern. Infection Control Hospital Epidemiology. 2020;41: 1371–72. doi.org/10.1017/ice.2020.381
Rose AN, Baggs J, Wolford H, Neuhauser MM, Srinivasan A, Gundlapalli A v., et al. Trends in antibiotic use in United States Hospitals during the coronavirus disease 2019 pandemic. Open Forum Infection Diseases. 2021 Jun;8(6):ofab236. doi: 10.1093/ofid/ofab236.
Burhan E, Susanto AD, Nasution SA, Ginanjar E, Pitoyo CW, Juzar DA, et al. Protokol tatalaksana COVID-19 edisi 1. Pehimpunan Dokter Paru Indonesia (PDPI), Dokter Spesialis Kardiovaskular Indonesia (PERKI), Dokter Spesialis Penyakit Dalam Indonesia (PAPDI), Dokter Anestesiologi dan Terapi Intensif Indonesia (PERDATIN), Ikatan Dokter Anak Indonesia (IDAI); 2020.
Fadila NR, Holik HA. Review Artikel: Fenomena panic buying terhadap obat-obatan pada masa pandemi COVID-19. Farmaka. 2021;19(4):68–75.
Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Therapeutic Advances in Drug Safety. 2014 Dec 16;5(6):229–41. doi: 10.1177/ 2042098614554919
World Health Organization. The ATC/DDD Methodology. WHO. 2023.
Sari A, Safitri I. Studi penggunaan antibiotika pasien pneumonia anak di RS PKU Muhammadiyah Yogyakarta dengan metode Defined Daily Dose (DDD). Jurnal Ilmiah Ibnu Sina. 2016;1(2):151-62.
Sandman Z, Iqbal OA. Azithromycin StatPearls [Internet]. 2023 Jan 15. [cited 2023 May 19].
Wahidah LK, Wahyuni NT, Putri DM. Evaluasi penggunaan antibiotik pneumonia dengan Metode Atc/ddd pada pasien pediatri di Instalasi Rawat Inap RSUD. Dr. a. Dadi Tjokrodipo Bandar Lampung Tahun 2019. Jurnal Farmasi Lampung. 2021 Mar 13;9(2):99–108. doi.org/10.37090/jfl.v9i2.338
Prasetyo EY, Kusumaratni DA. Evaluasi penggunaan antibiotika pada pasien pneumonia rawat inap di RS DKT Kota Kediri dengan Metode ATC-DDD Tahun 2018. In: Prosiding Seminar Nasional Farmasi, Institut Ilmu Kesehatan Bhakti Wiyata Kediri. 2018:Pg. 7–12.
Hanifah S, Meylani I, Madalena L. Evaluasi penggunaan antibiotik dengan metode ATC/DDD dan DU 90% pada pasien rawat inap kelompok staff medik penyakit di salah satu rumah sakit swasta di Kota Bandung. Farmaka. 2022;20(1):21–6.
Reijnders TDY, Saris A, Schultz MJ, van der Poll T. Immunomodulation by macrolides: therapeutic potential for critical care. Lancet Respiratory Medicine. 2020 Jun;8(6):619–30. doi: 10.1016/S2213-2600(20)30080-1.
Oliver ME, Hinks TSC. Azithromycin in viral infections. Reviews in Medical Virology.2022:13;31(2). doi.org/10.1002/rmv.2163
Bleyzac N, Goutelle S, Bourguignon L, Tod M. Azithromycin for COVID-19: More Than Just an Antimicrobial? Clinical Drug Investigation. 2020;40:683-86. doi.org/10.1007/s40261-020-00933-3
Sandeep S, McGregor K. Energetics based modeling of hydroxychloroquine and Azithromycin binding to the SARS-CoV-2 Spike (S)Protein - ACE2 Complex. ChemRxiv. 2020.
Karampela I, Dalamaga M. Could Respiratory Fluoroquinolones, Levofloxacin and Moxifloxacin, Prove to be Beneficial as an Adjunct Treatment in COVID-19? Archives of Medical Research. 2020;51(7):741-42 doi.org/10.1016/j.arcmed.2020.06.00
Marciniec K, Beberok A, Pęcak P, Boryczka S, Wrześniok D. Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis. Pharmacological Reports. 2020 Dec;72(6):1553-61. doi: 10.1007/s43440-020-00169-0.
Gbinigie K, Frie K. Should azithromycin be used to treat COVID-19? A rapid review. BJGP Open. 2020 Jun;4(2):bjgpopen20X101094. doi.org/10.3399/bjgpopen20X101094
Putra DE, Pramudo SG, Arkhaesi N, Retnoningrum D. Pola Pemberian Antibiotik di Era Pandemi Covid-19 (Studi Kasus di Rumah Sakit Nasional Diponegoro). Medica Hospitalia Journal of Clinical Medicine. 2021 Jul 15;8(2):194–9. doi:10.36408/mhjcm.v8i2.578
Anggraini W, Candra TM, Maimunah S, Sugihantoro H. Evaluasi kualitatif penggunaan antibiotik pada pasien Infeksi saluran kemih dengan metode Gyssens. KELUWIH: Jurnal Kesehatan dan Kedokteran. 2020 Dec 16;2(1):1–8. doi.org/10.24123/kesdok.V2i1.2876
Wibowo A, Aziz MA, Effendi JS, Tjahyadi. Evaluasi Rasionalisme Penggunaan Antibiotik dengan Metode Gyssens pada Pasien Seksio Sesarea di RSUP Hasan Sadikin Bandung Periode Januari-Desember 2018. Indonesian Journal of Obstetrics & Gynecology Science.2020 Sept ;3.(2):150-7.
Yusuf M, Auliah N, Sarambu HE. Evaluasi Penggunaan Antibiotik dengan metode Gyssens pada Pasien Pneumonia di Rumah Sakit Bhayangkara Kupang Periode Juli-Desember 2019. Jurnal Riset Kefarmasian Indonesia. 2022;4(2):215–29. doi.org/10.33759/jrki.v4i2.243.
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